Antidepressant Sweating: Why It Happens and What You Can Do

When you start taking an antidepressant, a medication used to treat depression, anxiety, and other mood disorders by balancing brain chemicals. Also known as antidepressive drugs, they help millions feel like themselves again—but not without side effects. One of the most confusing and embarrassing is antidepressant sweating, excessive, unexplained sweating triggered by certain antidepressants, especially SSRIs and SNRIs. It’s not just a hot flash or stress reaction. This sweat comes without warning, often at night, and doesn’t stop even when you’re cool and calm.

Why does this happen? Most antidepressants boost serotonin, a brain chemical that regulates mood, sleep, and body temperature. Too much serotonin can confuse your body’s thermostat, making you sweat even when you’re not overheated. This is especially common with SSRIs, selective serotonin reuptake inhibitors like fluoxetine, sertraline, and escitalopram. You might notice it after a dose increase, or even months into treatment. It’s not rare—studies show up to 20% of people on these drugs experience it. And while it’s usually harmless, it can be a sign of something more serious: serotonin syndrome, a rare but dangerous condition caused by too much serotonin, often from drug interactions. If you’re sweating heavily, plus have a fast heartbeat, confusion, or muscle stiffness, get help right away.

Some people try to quit their antidepressant because of the sweat. Don’t. Stopping suddenly can make depression worse and cause withdrawal symptoms. Instead, talk to your doctor. They might lower your dose, switch you to a different type of antidepressant, or add a medication like clonidine to help control the sweating. Lifestyle changes help too—wear breathable clothes, keep your bedroom cool, and avoid caffeine and spicy foods. You’re not alone in this. Many people deal with it and still find relief without giving up their treatment. Below, you’ll find real posts from people who’ve been there, with clear advice on managing this side effect, comparing antidepressants, and knowing when to push for a change.