Dapsone: What It Is, How It's Used, and What You Need to Know

When you hear Dapsone, a sulfone-type antibiotic used primarily to treat leprosy and certain skin conditions. Also known as diaminodiphenyl sulfone, it's one of the few drugs still in active use for leprosy, even after decades. Unlike most antibiotics that attack bacteria directly, Dapsone works by blocking the production of folic acid in microbes — a trick that stops them from multiplying. It’s not a go-to for every infection, but for specific diseases, it’s been a lifeline.

Dapsone isn’t just for leprosy. It’s also the go-to treatment for dermatitis herpetiformis, a chronic, itchy skin condition linked to gluten intolerance. Many people don’t realize this connection — the same drug that fights leprosy bacteria also calms the immune reaction in the skin. It’s also used off-label for other inflammatory skin disorders, like bullous pemphigoid and certain types of vasculitis. In some cases, doctors turn to Dapsone when other treatments fail, especially if the patient can’t tolerate steroids.

It’s not without risks. Dapsone can cause a drop in red blood cells, leading to anemia — especially in people with G6PD deficiency. That’s why blood tests are often required before and during treatment. It’s also known to cause headaches, nausea, or a blue-gray tint to the skin with long-term use. But for many, the benefits outweigh the side effects, especially when alternatives are limited or too expensive.

What’s interesting is how Dapsone fits into a broader picture of affordable, long-standing treatments. While new drugs come and go, Dapsone remains a staple in public health programs, especially in countries where leprosy is still present. It’s cheap, stable, and effective — qualities that make it irreplaceable in resource-limited settings. Even in Canada, where leprosy is rare, Dapsone is still prescribed for skin conditions, often through specialty pharmacies.

You won’t find Dapsone on every pharmacy shelf. It’s not an over-the-counter drug, and you usually need a prescription. But if you’re looking for reliable sources to get it — whether for yourself or someone you care for — you’ll find trusted options listed below. These posts cover everything from how it compares to other treatments, to what to expect when you start taking it, and how to manage side effects safely.